Jekeseni Kutentha Kuchotsa Technology

Ma pyrogen, omwe amadziwikanso kuti endotoxins, amapangidwa mu khoma la extracellular la mabakiteriya a gram-negative, ndiye kuti, zidutswa za mitembo ya bakiteriya.Ndi chinthu cha lipopolysaccharide chokhala ndi ma molekyulu ambiri kuyambira zikwi zingapo mpaka mazana angapo, kutengera mitundu ya mabakiteriya omwe amapanga.Mu aqueous solution, kuchuluka kwake kwa mamolekyu kumatha kusiyana kuchokera mazana masauzande mpaka mamiliyoni
Ngati kachulukidwe kakang'ono ka pyrogen kasakanizidwa mumankhwala ndikubayidwa m'magazi amunthu, kumayambitsa kutentha thupi kwambiri komanso imfa.Chifukwa chake, ndikofunikira kwambiri kuti muchepetse pyrogen mumadzi am'madzi momwe mungathere, makamaka pamene jekeseni (monga kulowetsedwa kwakukulu) mlingo ndi waukulu, kufunikira kwa pyrogen kuyenera kukhala kovuta kwambiri.

Depyrogenation yamadzimadzi a jakisoni (kapena madzi a jakisoni) ndi njira yoyambira yopanga mankhwala kuti ikwaniritse malamulo oyesa a Pharmacopoeia.Pakadali pano, njira za depyrogenation nthawi zambiri zimayambitsidwa m'magulu atatu awa:

1. Njira ya distillation imapanga madzi a depyrogenated, omwe amagwiritsidwa ntchito ngati madzi a jekeseni, kutsuka madzi, etc., koma mtengo wake ndi wokwera.
2. Depyrogenation ndi njira ya adsorption.Imodzi mwa njira ndi yakuti pamwamba adsorbent adsorbes zinthu pyrogenic ndi kulola kuti mankhwala zinthu kudutsa.Njira yachiwiri ndi yakuti adsorbent imatulutsa zinthu zomwe zimagwiritsidwa ntchito ndipo imalola kuti pyrogen ituluke.
3. Njira yolekanitsa ya ma membrane kuchotsa pyrogen monga njira yatsopano ndipo teknoloji yatsopano ikufalikira ndikugwiritsidwa ntchito m'makampani opanga mankhwala.Mfundo ya ultrafiltration kuchotsa pyrogen ndi kugwiritsa ntchito nembanemba ya ultrafiltration yaying'ono kusiyana ndi kulemera kwa molekyulu ya pyrogen kuti itseke pyrogen.Njira iyi yatsimikiziridwa.Ndipo ali ndi ubwino wa otsika kwambiri ntchito, mkulu zokolola za mankhwala ndi wabwino mankhwala.